Selected Publications

Primary Research

Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gardinaru V, Kampmann M, Kosik KS. LRP1 is a master regulator of tau uptake and spread. Nature. 2020. Apr;580(7803):381-385.

Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate AM, Fisher SK, Cuervo AM, Kosik KS. A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy. Sci Transl Med. 2019 Mar 27;11(485).

Krichevsky A. and Kosik KS: Neuronal RNA Granules: A Link between RNA Localization and Stimulation-dependent Translation. Neuron 32:683-696, 2001.

Martinez MC, Ochiishi T, Majewski M and Kosik KS: Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho J. Cell Biol 162:99-111, 2003.

Sakarya O, Armstrong KA, Adamska M, Adamski M, Wang IF, Tidor B, Degnan BM, Oakley TH, Kosik KS: A post-synaptic scaffold at the origin of the animal kingdom. PLoS ONE. 2007 Jun 6;2:e506 (editor’s choice, Science 316:1814, 2007; Faculty 1000 selection—Hidden Jewel in Neuroscience)

Kye MJ, Liu T, Levy SF, Xu NL, Groves BB, Bonneau R, Lao K, Kosik KS. Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR. RNA. 2007 Aug;13(8):1224-34. Epub 2007 Jun 25.

Carrettiero DC, Hernandez I, Neveu P, Papagiannakopoulos T, Kosik KS. The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule. J Neurosci. 2009 Feb 18;29(7):2151-61.

Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS: A Repressive Role for MicroRNA-145 on OCT4, SOX2, KLF4 and Human Embryonic Stem Cell Pluripotency. Cell 2009 May 15;137(4):647-58. Epub 2009 Apr 30.

Sakarya O, Conaco C, Eğecioğlu Ö, Solla SA, Oakley TH, Kosik KS: Evolutionary Expansion and Specialization of the PDZ Domains. Molecular Biology and Evolution 27(5):1058-69, 2010. Epub 2009 Dec 21.

Banerjee S, Neveu P and Kosik KS: A Coordinated Local Translational Control Point at the Synapse Involving Relief from Silencing and MOV10 Degradation. Neuron 24;64(6):871-84, 2009.

Conaco C, Bassett DS, Zhou H, Arcila ML, Degnan SM, Degnan BM, Kosik KS. Functionalization of a protosynaptic gene expression network. Proc Natl Acad Sci U S A. 2012 Jun 26;109 Suppl 1:10612-8. Epub 2012 Jun 20.

Arcila ML, Betizeau M, Cambronne XA, Guzman E, Doerflinger N, Bouhallier F, Zhou H, Wu B, Rani N, Bassett DS, Borello U, Huissoud C, Goodman RH, Dehay C, Kosik KS. Novel Primate miRNAs Coevolved with Ancient Target Genes in Germinal Zone-Specific Expression Patterns. Neuron. 2014 Feb 25. pii: S0896-6273(14)00022-1. doi: 10.1016/j.neuron.2014.01.017.

Lalli MA, Jang J., Joo-hye C. Park, Yidi Wang, Elmer Guzman, Hongjun Zhou, Morgane Audouard, Daniel Bridges, Kenneth R. Tovar, Sorina Mihaela Papuc, Andreea-Cristina Tutulan-Cunita, Yadong Huang, Magdalena Budisteanu, Aurora Arghir, Kenneth S. Kosik. Haploinsufficiency of BAZ1B Contributes to Williams Syndrome Through Transcriptional Dysregulation of Neurodevelopmental Pathways. Hum Mol Genet. 2016 Apr 1;25(7):1294-306. doi: 10.1093/hmg/ddw010.

Jang J, Wang Y, Lalli MA, Guzman E, Godshalk SE, Zhou H, Kosik KS. Primary Cilium-Autophagy-Nrf2 (PAN) Axis Activation Commits Human Embryonic Stem Cells to a Neuroectoderm Fate. Cell. 2016 Apr 7;165(2):410-20. doi: 10.1016/j.cell.2016.02.014.

Rani N, Nowakowski TJ, Zhou H, Godshalk SE, Lisi V, Kriegstein AR, Kosik KS. A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA. Neuron. 2016 Jun 15;90(6):1174-88. doi: 10.1016/j.neuron.2016.05.005. Epub 2016 Jun 2. PMID: 27263970 Editors' Choice Science 22 Jul 2016: Vol. 353, Issue 6297, pp. 360

Zhang X, Lin Y, Eschmann NA, Zhou H, Rauch JN, Hernandez I, Guzman E, Kosik KS, Han S. RNA stores tau reversibly in complex coacervates. PLoS Biol. 2017 Jul 6;15(7):e2002183. doi: 10.1371/journal.pbio.2002183. eCollection 2017 Jul. PMID: 28683104

Tovar KR, Bridges DC, Wu B, Randall C, Audouard M, Jang J, Hansma PK, Kosik KS. Action potential propagation recorded from single axonal arbors using multi-electrode arrays. J Neurophysiol. 2018 Apr 11. doi: 10.1152/jn.00659.2017. PMID: 29641308

Rauch JN, Chen JJ, Sorum AW, Miller GM, Sharf T, See SK, Hsieh-Wilson LC, Kampmann M, Kosik KS. Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs). Sci Rep. 2018 Apr 23;8(1):6382. doi: 10.1038/s41598-018-24904-z.

Nowakowski TJ, Rani N, Golkaram M, Zhou HR, Alvarado B, Huch K, West JA, Leyrat A, Pollen AA, Kriegstein AR, Petzold LR, Kosik KS: Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development. Nat Neurosci. (12):1784-1792, 2018.

Reviews

Kosik KS. MicroRNAs and cellular phenotypy. Cell. 2010 Oct 1;143(1):21-6.

Kosik KS, Sejnowski TJ, Raichle ME, Ciechanover A, Baltimore D. A path toward understanding neurodegeneration. Science. 2016 Aug 26;353(6302):872-3. doi: 10.1126/science.aai7622.

Kosik KS : Life at Low Copy Number: How Dendrites Manage with So Few mRNAs. Neuron. 2016 Dec 21;92(6):1168-1180. doi: 10.1016/j.neuron.2016.11.002.

Kosik KS, Nowakowski T. Evolution of New miRNAs and Cerebro-Cortical Development. Annu Rev Neurosci. 2018 Apr 4. doi: 10.1146/annurev-neuro-080317-061822. [Epub ahead of print]