Selected Publications

Primary Research

• Sepulveda-Falla D, Villegas Lanau CA, White Iii C, Serrano GE, Acosta-Uribe J, Mejía-Cupajita B, Villalba-Moreno ND, Lu P, Glatzel M, Kofler JK, Ghetti B, Frosch MP, Restrepo FL, Kosik KS, Beach TG. Comorbidities in early-onset sporadic versus presenilin-1 mutation-associated Alzheimer disease dementia: Evidence for dependency on Alzheimer disease neuropathological changes. J Neuropathol Exp Neurol. 2025 Feb 1. 84(2):104-113.
• Longhini AP, DuBose A, Lobo S, Vijayan V, Bai Y, Rivera EK, Sala-Jarque J, Nikitina A, Carrettiero DC, Unger MT, Sclafani OR, Fu V, Beckett ER, Vigers M, Buee L, Landrieu I, Shell S, Shea JE, Han S, Kosik KS. Precision proteoform design for 4R tau isoform selective templated aggregation. Proceedings of the National Academy of Sciences. 2024. 121, e2320456121. 10.1073/pnas.2320456121.
• Acosta‐Uribe J, Villegas‐Lanau A, Vallejo D, Ramírez‐Aguilar L, Solano JM, Mejía‐Cupajita B ... and Giraldo‐Chica M. Primary lateral sclerosis associated with PSEN1 Pro284Leu variant in a Colombian family: Clinical and neuropathological features. Alzheimer's & Dementia. 2024. 20(9), 6384-6394.
• Almeida MC, Eger SJ, He C, Audouard M, Nikitina A, Glasauer SM, Han D, Mejía-Cupajita B, Acosta-Uribe J, Villalba-Moreno ND, Littau JL. et al. Single-nucleus RNA sequencing demonstrates an autosomal dominant Alzheimer’s disease profile and possible mechanisms of disease protection. Neuron. 2024 Feb 21.
• Bai Y, Camargo CM, Glasauer SMK, Gifford R, Tian X, Longhini AP, and Kosik KS. Single-cell mapping of lipid metabolites using an infrared probe in human-derived model systems. Nature Communications. 2024. 15(1), 350.
• Cochran JN, Acosta-Uribe J, Esposito BT, Madrigal L, Aguillón D, Giraldo MM, Taylor JW, Bradley J, Fulton-Howard B, Andrews SJ, Acosta-Baena N, Alzate D, Garcia GP, Piedrahita F, Lopez HE, Anderson AG, Rodriguez-Nunez I, Roberts K, Dominantly Inherited Alzheimer Network, Absher D, Myers RM, Beecham GW, Reitz C, Rizzardi LF, Fernandez MV, Goate AM, Cruchaga C, Renton AE, Lopera F, Kosik KS. Genetic associations with age at dementia onset in the PSEN1 E280A Colombian kindred. Alzheimers Dement. 2023 Mar 23.
• Han D, Liu G, Oh Y, Oh S, Yang S, Mandjikian L, Rani N, Almeida MC, Kosik KS, Jang J. ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells. Nat Commun. 2023 Feb 9;14(1):632.
• Glasauer SMK, Goderie SK, Rauch JN, Guzman E, Audouard M, Bertucci T, Joy S, Rommelfanger E, Luna G, Keane-Rivera E, Lotz S, Borden S, Armando AM, Quehenberger O, Temple S, Kosik KS. Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol. Stem Cell Reports. 2022 Sep 13;17(9):2127-2140.
• Acosta-Uribe J, Aguillón D, Cochran JN, Giraldo M, Madrigal L, Killingsworth BW ... and Kosik KS. A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects. Genome Med. 2022. 14, 27.
• Sharf T, van der Molen T, Glasauer SMK, Guzman E, Buccino AP, Luna G, Cheng Z, Audouard M, Ranasinghe KG, Kudo K, Nagarajan SS, Tovar KR, Petzold LR, Hierlemann A, Hansma PK, Kosik KS. Functional neuronal circuitry and oscillatory dynamics in human brain organoids. Nat Commun. 2022 Jul 29;13(1):4403.
• Sepulveda-Falla D, Sanchez JS, Almeida MC, Boassa D, Acosta-Uribe J, Vila-Castelar C, Ramirez-Gomez L, Baena A, Aguillon D, Villalba-Moreno ND, Littau JL, Villegas A, Beach TG, White CL 3rd, Ellisman M, Krasemann S, Glatzel M, Johnson KA, Sperling RA, Reiman EM, Arboleda-Velasquez JF, Kosik KS, Lopera F, Quiroz YT. Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia.Acta Neuropathol. 2022 Sep;144(3):589-601.
• Carrettiero DC, Almeida MC, Longhini AP, Rauch JN, Han D, Zhang X, Najafi S, Gestwicki JE, Kosik KS. Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate. Nat Commun. 2022 Jun 2;13(1):3074.
• Acosta-Uribe J, Aguillón D, Cochran JN, Giraldo M, Madrigal L, Killingsworth BW, Singhal R, Labib S, Alzate D, Velilla L, Moreno S, García GP, Saldarriaga A, Piedrahita F, Hincapié L, López HE, Perumal N, Morelo L, Vallejo D, Solano JM, Reiman EM, Surace EI, Itzcovich T, Allegri R, Sánchez-Valle R, Villegas-Lanau A, White CL 3rd, Matallana D, Myers RM, Browning SR, Lopera F, Kosik KS. A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects.Genome Med. 2022 Mar 8;14(1):27.
• Han D, Longhini AP, Zhang X, Hoang V, Wilson MZ, Kosik KS. Dynamic assembly of the mRNA m6A methyltransferase complex is regulated by METTL3 phase separation. PLoS Biol. 2022 Feb 10;20(2):e3001535.
• Karzbrun E, Khankhel AH, Megale HC, Glasauer SMK, Wyle Y, Britton G, Warmflash A, Kosik KS, Siggia ED, Shraiman BI, Streichan SJ. Human neural tube morphogenesis in vitro by geometric constraints. Nature. 2021 Nov;599(7884):268-272.
• Guzman E, Cheng Z, Hansma PK, Tovar KR, Petzold LR, Kosik KS. Extracellular detection of neuronal coupling. Sci Rep. 2021 Jul 19;11(1):14733.
• Najafi S, Lin Y, Longhini AP, Zhang X, Delaney KT, Kosik KS, Fredrickson GH, Shea JE, Han S. Liquid-liquid phase separation of Tau by self and complex coacervation. Protein Sci. 2021 Jul;30(7):1393-1407.
• Ehrenberg AJ, Leng K, Letourneau KN, Hernandez I, Lew C, Seeley WW, Spina S, Miller B, Heinsen H, Kampmann M, Kosik KS, Grinberg LT. Patterns of neuronal Rhes as a novel hallmark of tauopathies. Acta Neuropathol. 2021 May;141(5):651-666.
• Lin Y, Fichou Y, Longhini AP, Llanes LC, Yin P, Bazan GC, Kosik KS, Han S. Liquid-Liquid Phase Separation of Tau Driven by Hydrophobic Interaction Facilitates Fibrillization of Tau. J Mol Biol. 2021 Jan 22;433(2):166731.
• Wesseling H, Mair W, Kumar M, Schlaffner CN, Tang S, Beerepoot P, Fatou B, Guise AJ, Cheng L, Takeda S, Muntel J, Rotunno MS, Dujardin S, Davies P, Kosik KS, Miller BL, Berretta S, Hedreen JC, Grinberg LT, Seeley WW, Hyman BT, Steen H, Steen JA. Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease. Cell. 2020 Dec 10;183(6):1699-1713.e13.
• Zhang X, Vigers M, McCarty J, Rauch JN, Fredrickson GH, Wilson MZ, Shea JE, Han S, Kosik KS. The proline-rich domain promotes Tau liquid-liquid phase separation in cells. J Cell Biol. 2020 Nov 2;219(11):e202006054.
• Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gardinaru V, Kampmann M, Kosik KS. LRP1 is a master regulator of tau uptake and spread. Nature. 2020. Apr;580(7803):381-385.
• Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate AM, Fisher SK, Cuervo AM, Kosik KS. A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy. Sci Transl Med. 2019 Mar 27;11(485).
• Rauch JN, Chen JJ, Sorum AW, Miller GM, Sharf T, See SK, Hsieh-Wilson LC, Kampmann M, Kosik KS. Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs). Sci Rep. 2018 Apr 23;8(1):6382. doi: 10.1038/s41598-018-24904-z.
• Nowakowski TJ, Rani N, Golkaram M, Zhou HR, Alvarado B, Huch K, West JA, Leyrat A, Pollen AA, Kriegstein AR, Petzold LR, Kosik KS: Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development. Nat Neurosci. 2018. (12):1784-1792.
• Zhang X, Lin Y, Eschmann NA, Zhou H, Rauch JN, Hernandez I, Guzman E, Kosik KS, Han S. RNA stores tau reversibly in complex coacervates. PLoS Biol. 2017 Jul 6;15(7):e2002183. doi: 10.1371/journal.pbio.2002183. eCollection 2017 Jul. PMID: 28683104.
• Tovar KR, Bridges DC, Wu B, Randall C, Audouard M, Jang J, Hansma PK, Kosik KS. Action potential propagation recorded from single axonal arbors using multi-electrode arrays. J Neurophysiol. 2018 Apr 11. doi: 10.1152/jn.00659.2017. PMID: 29641308
• Rani N, Nowakowski TJ, Zhou H, Godshalk SE, Lisi V, Kriegstein AR, Kosik KS. A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA. Neuron. 2016 Jun 15;90(6):1174-88. doi: 10.1016/j.neuron.2016.05.005. Epub 2016 Jun 2. PMID: 27263970 Editors' Choice Science 22 Jul 2016: Vol. 353, Issue 6297, pp. 360.
• Jang J, Wang Y, Lalli MA, Guzman E, Godshalk SE, Zhou H, Kosik KS. Primary Cilium-Autophagy-Nrf2 (PAN) Axis Activation Commits Human Embryonic Stem Cells to a Neuroectoderm Fate. Cell. 2016 Apr 7;165(2):410-20. doi: 10.1016/j.cell.2016.02.014.
• Lalli MA, Jang J., Joo-hye C. Park, Yidi Wang, Elmer Guzman, Hongjun Zhou, Morgane Audouard, Daniel Bridges, Kenneth R. Tovar, Sorina Mihaela Papuc, Andreea-Cristina Tutulan-Cunita, Yadong Huang, Magdalena Budisteanu, Aurora Arghir, Kenneth S. Kosik. Haploinsufficiency of BAZ1B Contributes to Williams Syndrome Through Transcriptional Dysregulation of Neurodevelopmental Pathways. Hum Mol Genet. 2016 Apr 1;25(7):1294-306. doi: 10.1093/hmg/ddw010.
• Arcila ML, Betizeau M, Cambronne XA, Guzman E, Doerflinger N, Bouhallier F, Zhou H, Wu B, Rani N, Bassett DS, Borello U, Huissoud C, Goodman RH, Dehay C, Kosik KS. Novel Primate miRNAs Coevolved with Ancient Target Genes in Germinal Zone-Specific Expression Patterns. Neuron. 2014 Feb 25. pii: S0896-6273(14)00022-1. doi: 10.1016/j.neuron.2014.01.017.
• Conaco C, Bassett DS, Zhou H, Arcila ML, Degnan SM, Degnan BM, Kosik KS. Functionalization of a protosynaptic gene expression network. Proc Natl Acad Sci U S A. 2012 Jun 26;109 Suppl 1:10612-8. Epub 2012 Jun 20.
• Sakarya O, Conaco C, Eğecioğlu Ö, Solla SA, Oakley TH, Kosik KS: Evolutionary Expansion and Specialization of the PDZ Domains. Molecular Biology and Evolution 27(5):1058-69, 2010. Epub 2009 Dec 21.
• Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS: A Repressive Role for MicroRNA-145 on OCT4, SOX2, KLF4 and Human Embryonic Stem Cell Pluripotency. Cell 2009 May 15;137(4):647-58. Epub 2009 Apr 30.
• Carrettiero DC, Hernandez I, Neveu P, Papagiannakopoulos T, Kosik KS. The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule. J Neurosci. 2009 Feb 18;29(7):2151-61.
• Banerjee S, Neveu P and Kosik KS: A Coordinated Local Translational Control Point at the Synapse Involving Relief from Silencing and MOV10 Degradation. Neuron 24;64(6):871-84, 2009.
• Kye MJ, Liu T, Levy SF, Xu NL, Groves BB, Bonneau R, Lao K, Kosik KS. Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR. RNA. 2007 Aug;13(8):1224-34. Epub 2007 Jun 25.
• Sakarya O, Armstrong KA, Adamska M, Adamski M, Wang IF, Tidor B, Degnan BM, Oakley TH, Kosik KS: A post-synaptic scaffold at the origin of the animal kingdom. PLoS ONE. 2007 Jun 6;2:e506 (editor’s choice, Science 316:1814, 2007; Faculty 1000 selection—Hidden Jewel in Neuroscience)
• Martinez MC, Ochiishi T, Majewski M and Kosik KS: Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho J. Cell Biol 162:99-111, 2003.
• Krichevsky A. and Kosik KS: Neuronal RNA Granules: A Link between RNA Localization and Stimulation-dependent Translation. Neuron 32:683-696, 2001.

Reviews

• Kosik KS. MicroRNAs and cellular phenotypy. Cell. 2010 Oct 1;143(1):21-6.
• Kosik KS, Sejnowski TJ, Raichle ME, Ciechanover A, Baltimore D. A path toward understanding neurodegeneration. Science. 2016 Aug 26;353(6302):872-3. doi: 10.1126/science.aai7622.
• Kosik KS : Life at Low Copy Number: How Dendrites Manage with So Few mRNAs. Neuron. 2016 Dec 21;92(6):1168-1180. doi: 10.1016/j.neuron.2016.11.002.
• Kosik KS, Nowakowski T. Evolution of New miRNAs and Cerebro-Cortical Development. Annu Rev Neurosci. 2018 Apr 4. doi: 10.1146/annurev-neuro-080317-061822. [Epub ahead of print]