Luana Fioriti

The ultimate goal of my research is to design novel therapeutic approaches to prevent or delay the onset of neurodegenerative as well as infectious disease. To this end, I recently started to investigate the role of post-translational modifications in the modulation of aggregation, toxicity and release of aggregation prone proteins, such as tau, Htt, synuclein and Nucleocapsid. I study  the role of SUMOylation as a regulator of  protein aggregation and toxicity in vitro and in mice models of Alzheimer's Disease and frontotemporal dementia.