Credit: Gabriel Luna

Using molecular, cellular tools and disease models, we would like to better understand and treat neurodegenerative diseases. Protein tau has been a long time interest, is a common neuronal protein that, under circumstances and conditions not well understood to date, self-assembles into intracellular aggregates in several neurodegenerative diseases including Alzheimer's. The mechanism by which this critical transition from a soluble protein to insoluble fibrous material occurs is unknown. We are currently tackling the problem combining several approaches. 1) transgenic mouse models. 2) patient fibroblast-derived IPS neurons. 3) in vitro biochemistry and CRISPRi screening. 4) RNA-seq and bioinformatics analysis.

Affiliated Researchers

Principal Investigator
Exploration of fundamental biological processes, particularly those related to the brain and its evolution.
Undergraduate Researcher
Delta-catenin, a protein which regulates synaptic density and plasticity in neurons and has been linked to multiple neurodevelopmental disorders such as Autism and Cris-du-chat.
Postdoctoral Researcher
Studying early human brain development and consequences of pathogenic MAPT mutations using stem cell derived organoids, imaging and single cell transcriptomics.
Ph.D. Student + Sequencing Facility Assistant Director
Exploring the functional synaptic connectivity of cultured neuronal networks and developing methods to quantify biological events in these systems.
Postdoctoral Researcher
Liquid-liquid phase separation, CRISPRi screening, Embryonic stem cells, Non-coding RNAs, Cell fate determination.
Postdoctoral Researcher
Interested in the pathobiology of Tau in neurodegenerative diseases.
Postdoctoral Researcher

Neurodegeneration, RNA biology, lncRNA, tau protein, LLPS.

Associate Specialist
Examining and documenting the pathobiology of tauopathies using multimodal microscopy.
Lab Manager

Synaptic plasticity.

Postdoctoral Researcher
Focused on understanding the molecular mechanisms of tau aggregation and spread using in vitro biochemistry, cellular, and animal model systems.
Associate specialist
Catching tau in liquid-liquid phase separation.

Collaborators

Songi Han (UCSB), Yann Fichou (UCSB), Martin Kampmann (UCSF)