Neurophysiology

A critical barrier towards advancing our understanding of impaired cognitive function in mental illness and its treatment is the overwhelming complexity of the brain’s microcircuitry. This deficit severely limits our ability to understand and draw conclusions about the nature of mental illness within the brain and the impact of pharmacological interventions intended to treat them. To overcome this challenge, we use multi-electrode arrays (MEAs) to investigate the electrical property of hundreds of networked neurons in controlled laboratory conditions, where we can generate spatiotemporal maps with sub-millisecond temporal resolution. We then apply this information to investigate basic features governing the formation and development neural circuitry and their implications in the context of neurodegeneration. To accomplish this, we work with transgenic mouse models as well as patient-derived induced pluripotent stem cells (iPSCs) with the aim to uncover how genetic deficits impact electrical signaling within neural circuits.

Affiliated Researchers

Principal Investigator
Exploration of fundamental biological processes, particularly those related to the brain and its evolution.
Graduate Student Researcher
Discovering neurophysiologic dysfunction in tau pathology.
Ph.D. Student + Sequencing Facility Assistant Director
Exploring the functional synaptic connectivity of cultured neuronal networks and developing methods to quantify biological events in these systems.
Undergraduate Researcher
Studying tau pathology and neurophysiology in cultured neuronal stem cells and mouse primary cells with MEAs.
Postdoctoral Researcher
Interested in the pathobiology of Tau in neurodegenerative diseases.
Postdoctoral Researcher
Developing devices to investigate neural circuitry with the aim to uncover general rules to explain how they malfunction with disease and mental illness.
Associate Project Scientist
Discovering electrophysiologic features of neurons grown on multi-electrode arrays.

Collaborators

Linda Petzold (UCSB), Paul Hansma (UCSB), Mahdi Golkaram (UCSB), Destinee Cheng (UCSB), Yun Zhao (UCSB)