Neurophysiology

We have developed an extensive data set that characterizes the neurophysiology of human and mouse brain organoids for a potential role as computational units and storage of memory traces. The technologies include dense multi-electrode arrays (MEAs), wireless MEAs, calcium dye imagining by two-photon, and optogenetics and computational inferences of neural circuitry. Applications include the study of drug effects (ketamine and benzodiazopines) and anesthetics (Xenon).

Affiliated Researchers

Kenneth S. Kosik

Principal Investigator
Exploration of fundamental biological processes, particularly those related to the brain and its evolution.
Stem Cells and Neurodevelopment
Cellular Neurobiology and Pathobiology
Genomics
Neurophysiology

Christian Bustamante

Graduate Student Researcher
Studying malfunctions in neural circuit activity that result in disease and mental illness, in order to develop appropriate treatments.
Neurophysiology

Angela Bontempo

Postdoctoral Researcher
Exploring how sensory input shapes the development and learning capacity of human cortical organoids.
Neurophysiology

Carla Ladd

Postdoctoral Researcher
Using optogenetics and calcium sequencing to study neuronal activity in brain organoids.
Stem Cells and Neurodevelopment

Tjitse Van der Molen

Postdoctoral Researcher

Exploring the activity of neural circuits, using dense multi electrode arrays to make high resolution spatiotemporal re

Stem Cells and Neurodevelopment
Neurophysiology

Collaborators

  • Paul Hansma (UCSB)
  • Tal Sharf (UCSC)
  • Brad Chelmka (UCSB)
  • Ruifeng Han (UCSB)
  • Dirk Bouwmeester (UCSB)
  • Hartmut Nevin (Google Quantum AI)
  • Lev Loffe (Google Quantum AI)
  • Christof Koch (Allen Brain Institute)
  • Kenneth Shepard (Columbia University)