We explore the biology of neuronal fate establishment and neuronal differentiation in stem cells and Induced pluripotent cells, in the context of normal development and neurodevelopmental disorders such as Williams Syndrome, or in the context of neurodegenerative diseases associated to Tau such as Frontotemporal dementia, in cells carrying Tau mutations. To promote discovery in this area we use state-of-the art techniques including 3D cell culturing and cerebral organoids production in suspension cultures, and viral-mediated direct reprogramming. High-throughput data of cellular identity is analyzed by an array of methods including fluorescent confocal microscopy, multi-electrode array electrophysiological analysis, and single-cell RNA sequencing.
Affiliated Researchers
Collaborators
Jiwon Jang (Postech), Eyal Karbrun (UCSB), Sebastian J Streichan (UCSB)
