Credit: Mukund Hari

We explore the biology of neuronal fate establishment and neuronal differentiation in stem cells and Induced pluripotent cells, in the context of normal development and neurodevelopmental disorders such as Williams Syndrome, or in the context of neurodegenerative diseases associated to Tau such as Frontotemporal dementia, in cells carrying Tau mutations. To promote discovery in this area we use state-of-the art techniques including 3D cell culturing and cerebral organoids production in suspension cultures, and viral-mediated direct reprogramming. High-throughput data of cellular identity is analyzed by an array of methods including fluorescent confocal microscopy, multi-electrode array electrophysiological analysis, and single-cell RNA sequencing.

Affiliated Researchers

Principal Investigator
Exploration of fundamental biological processes, particularly those related to the brain and its evolution.
SRA IV, lab manager
Focused on modelling Williams Syndrome and duplication syndrome with iPS-derived neurons using electrophysiology and single cell RNA sequencing.
Undergraduate Researcher
Delta-catenin, a protein which regulates synaptic density and plasticity in neurons and has been linked to multiple neurodevelopmental disorders such as Autism and Cris-du-chat.
Postdoctoral Researcher
Studying early human brain development and consequences of pathogenic MAPT mutations using stem cell derived organoids, imaging and single cell transcriptomics.
Postdoctoral Researcher
Liquid-liquid phase separation, CRISPRi screening, Embryonic stem cells, Non-coding RNAs, Cell fate determination.
Undergraduate Researcher
Studying tau pathology and neurophysiology in cultured neuronal stem cells and mouse primary cells with MEAs.
Postdoctoral Researcher
Interested in the pathobiology of Tau in neurodegenerative diseases.
Postdoctoral Researcher

Exploring the regulatory cascades for neurodevelopment and stem cell differentiation and functionality of retrotransposons.

Postdoctoral Researcher

Neurodegeneration, RNA biology, lncRNA, tau protein, LLPS.

Collaborators

Jiwon Jang (Postech), Eyal Karbrun (UCSB), Sebastian J Streichan (UCSB)